picornavirusPronunciation: /pɪˈkɔːnəˌvʌɪrəs/Definition of picornavirus noun any of a group of very small RNA viruses which includes enteroviruses, rhinoviruses, and the virus of foot-and-mouth disease. Origin: 1960s: from pico- + RNA + viruspicornavirus in other Oxford dictionaries Definition of picornavirus in the US English dictionary