phenylephrinePronunciation: /ˌfiːnʌɪlˈɛfrɪn, ˌfɛnɪl-, -ˈɛfriːn/Definition of phenylephrine noun [mass noun] Medicine a synthetic compound related to adrenaline, used as a vasoconstrictor and nasal decongestant. Origin: 1940s: from phenyl + a contraction of epinephrinephenylephrine in other Oxford dictionaries Definition of phenylephrine in the US English dictionary