phentolaminePronunciation: /fɛnˈtɒləmiːn/Definition of phentolamine noun [mass noun] Medicine a synthetic compound used as a vasodilator, especially in certain cases of hypertension. Origin: 1950s: from phen- + tol(yl) (an isomeric cyclic radical derived from toluene) + aminephentolamine in other Oxford dictionaries Definition of phentolamine in the US English dictionary