papillomaPronunciation: /ˌpapɪˈləʊmə/Definition of papilloma noun (plural papillomas or papillomata /-mətə/) Medicine a small wart-like growth on the skin or on a mucous membrane, derived from the epidermis and usually benign. Origin: mid 19th century: from papilla + -omapapilloma in other Oxford dictionaries Definition of papilloma in the US English dictionary