papainPronunciation: /pəˈpeɪɪn, pəˈpʌɪɪn/Definition of papain noun [mass noun] a protein-digesting enzyme obtained from unripe papaya fruit, used to tenderize meat and as a food supplement to aid digestion. Origin: late 19th century: from papaya + -in1papain in other Oxford dictionaries Definition of papain in the US English dictionary