otosclerosisPronunciation: /ˌəʊtə(ʊ)skləˈrəʊsɪs/Definition of otosclerosis noun [mass noun] Medicine a hereditary disorder causing progressive deafness due to overgrowth of bone in the inner ear. Derivatives otosclerotic adjective otosclerosis in other Oxford dictionaries Definition of otosclerosis in the US English dictionary