osteosarcomaPronunciation: /ˌɒstɪəʊsɑːˈkəʊmə/Definition of osteosarcoma noun (plural osteosarcomas or osteosarcomata /-mətə/) Medicine a malignant tumour of bone in which there is a proliferation of osteoblasts. osteosarcoma in other Oxford dictionaries Definition of osteosarcoma in the US English dictionary