osteoclastPronunciation: /ˈɒstɪə(ʊ)klast/Definition of osteoclast noun Physiology a large multinucleate bone cell which absorbs bone tissue during growth and healing. Derivatives osteoclastic adjective Origin: late 19th century: from osteo- 'bone' + Greek klastēs 'breaker'osteoclast in other Oxford dictionaries Definition of osteoclast in the US English dictionary