ossiclePronunciation: /ˈɒsɪk(ə)l/Definition of ossicle noun Anatomy & Zoology a very small bone, especially one of those in the middle ear. Zoology a small piece of calcified material forming part of the skeleton of an invertebrate animal such as an echinoderm. Origin: late 16th century: from Latin ossiculum, diminutive of os 'bone'ossicle in other Oxford dictionaries Definition of ossicle in the US English dictionary