osmoregulationPronunciation: /ˌɒzməʊrɛgjʊˈleɪʃ(ə)n/Definition of osmoregulation noun [mass noun] Biology the maintenance of constant osmotic pressure in the fluids of an organism by the control of water and salt concentrations. Derivatives osmoregulatory adjective osmoregulation in other Oxford dictionaries Definition of osmoregulation in the US English dictionary