oestradiolPronunciation: /ˌiːstrəˈdʌɪɒl, ˌɛstrə-/ (US estradiol)Definition of oestradiol noun [mass noun] Biochemistry a major oestrogen produced in the ovaries. Origin: 1930s: from oestrus + di-1 + -oloestradiol in other Oxford dictionaries Definition of oestradiol in the US English dictionary