nicotinePronunciation: /ˈnɪkətiːn/Translate nicotine | into French | into German | into Italian | into Spanish Definition of nicotine noun [mass noun] a toxic colourless or yellowish oily liquid which is the chief active constituent of tobacco. It acts as a stimulant in small doses, but in larger amounts blocks the action of autonomic nerve and skeletal muscle cells. An alkaloid; chemical formula: C10H14N2 Origin: early 19th century: from French, from nicotiana + -ine4nicotine in other Oxford dictionaries Definition of nicotine in the US English dictionary