neurolepticPronunciation: /ˌnjʊərə(ʊ)ˈlɛptɪk/ MedicineDefinition of neuroleptic adjective (of a drug) tending to reduce nervous tension by depressing nerve functions. noun a neuroleptic drug; a major tranquillizer. Origin: 1950s: from neuro- 'relating to nerves' + -leptic, as in organolepticneuroleptic in other Oxford dictionaries Definition of neuroleptic in the US English dictionary