neoprenePronunciation: /ˈniːə(ʊ)priːn/Definition of neoprene noun [mass noun] a synthetic polymer resembling rubber, resistant to oil, heat, and weathering. Origin: 1930s: from neo- 'new' + prene (perhaps from propyl + -ene), on the pattern of words such as chloropreneneoprene in other Oxford dictionaries Definition of neoprene in the US English dictionary