naganaPronunciation: /nəˈgɑːnə/Definition of nagana noun [mass noun] a disease of cattle, antelope, and other livestock in southern Africa, characterized by fever, lethargy, and oedema, and caused by trypanosome parasites transmitted by the tsetse fly. Origin: late 19th century: from Zulu nakanenagana in other Oxford dictionaries Definition of nagana in the US English dictionary