myxoedemaPronunciation: /ˌmɪksɪˈdiːmə/ (US myxedema)Definition of myxoedema noun [mass noun] Medicine swelling of the skin and underlying tissues giving a waxy consistency, typical of patients with underactive thyroid glands. the more general condition associated with hypothyroidism, including weight gain, mental dullness, and sensitivity to cold. myxoedema in other Oxford dictionaries Definition of myxoedema in the US English dictionary