muscadinePronunciation: /ˈmʌskədɪn, -ʌɪn/Definition of muscadine noun any of a group of species and varieties of wine grape native to Mexico and the south-eastern US, typically having thick skins and a musky flavour. Genus Vitis (section Muscadinia): several species, in particular V. rotundifolia Origin:probably an alteration of muscatelmuscadine in other Oxford dictionaries Definition of muscadine in the US English dictionary