missusPronunciation: /ˈmɪsəz/ (also missis)Definition of missus noun informal or humorous a man’s wife:I promised the missus I’d be home by eleven British informal used as a form of address to a woman whose name is not known:sit down, missusOrigin: late 18th century: representing an informal pronunciation of mistress; compare with Mrsmissus in other Oxford dictionaries Definition of missus in the US English dictionary