metoprololPronunciation: /mɪˈtɒprəlɒl/Definition of metoprolol noun [mass noun] Medicine a beta-blocking drug related to propranolol, used to treat hypertension and angina. Origin: 1970s: from met- (from methyl) + pro(prano)lolmetoprolol in other Oxford dictionaries Definition of metoprolol in the US English dictionary