mesospherePronunciation: /ˈmɛsə(ʊ)sfɪə, ˈmɛz-, ˈmiːs-, ˈmiːz-/Definition of mesosphere noun the region of the earth’s atmosphere above the stratosphere and below the thermosphere, between about 50 and 80 km in altitude. mesosphere in other Oxford dictionaries Definition of mesosphere in the US English dictionary