mesophyllPronunciation: /ˈmɛsə(ʊ)fɪl, ˈmɛz-, ˈmiːs-, ˈmiːz-/Definition of mesophyll noun [mass noun] Botany the inner tissue (parenchyma) of a leaf, containing many chloroplasts. Origin: mid 19th century: from meso- 'middle' + Greek phullon 'leaf'mesophyll in other Oxford dictionaries Definition of mesophyll in the US English dictionary