mesodermPronunciation: /ˈmɛsə(ʊ)dəːm, ˈmɛz-, ˈmiːs-, ˈmiːz-/Definition of mesoderm noun [mass noun] Embryology the middle layer of cells or tissues of an embryo, or the parts derived from this (e.g. cartilage, muscles, and bone). Derivatives mesodermalPronunciation: /mɛsə(ʊ)ˈdəːm(ə)l, mɛz-, miːs-, miːz-/ adjective Origin: late 19th century: from meso- 'middle' + Greek derma 'skin'mesoderm in other Oxford dictionaries Definition of mesoderm in the US English dictionary