mesenchymePronunciation: /ˈmɛsəŋkʌɪm, ˈmiːz-/Definition of mesenchyme noun [mass noun] Embryology a loosely organized, mainly mesodermal embryonic tissue which develops into connective and skeletal tissues, including blood and lymph. Derivatives mesenchymal adjective Origin: late 19th century: from Greek mesos 'middle' + enkhuma 'infusion'mesenchyme in other Oxford dictionaries Definition of mesenchyme in the US English dictionary