mescalPronunciation: /ˈmɛskal, mɛˈskal/Definition of mescal noun 1another term for maguey. [mass noun] an alcoholic drink distilled from the sap of an agave. 2another term for peyote.Origin: early 18th century: from Spanish mezcal, from Nahuatl mexcallimescal in other Oxford dictionaries Definition of mescal in the US English dictionary