melanocyte-stimulating hormone Syllabification: (me·lan·o·cyte-stim·u·lat·ing hor·mone)Entry from US Dictionary (abbreviation: MSH)Definition of melanocyte-stimulating hormone noun Physiology a hormone secreted by the pituitary gland that is involved in pigmentation changes in some animals. melanocyte-stimulating hormone in other Oxford dictionaries Definition of melanocyte-stimulating hormone in the US English dictionary