mainframePronunciation: /ˈmeɪnfreɪm/Translate mainframe | into French | into German | into Italian | into Spanish Definition of mainframe noun 1a large high-speed computer, especially one supporting numerous workstations or peripherals: [as modifier]:cumbersome mainframe systems 2the central processing unit and primary memory of a computer. mainframe in other Oxford dictionaries Definition of mainframe in the US English dictionary
