macromoleculePronunciation: /ˌmakrə(ʊ)ˈmɒlɪkjuːl/Definition of macromolecule noun Chemistry a molecule containing a very large number of atoms, such as a protein, nucleic acid, or synthetic polymer. Derivatives macromolecularPronunciation: /-məˈlɛkjʊlə/ adjective macromolecule in other Oxford dictionaries Definition of macromolecule in the US English dictionary