macroevolutionPronunciation: /ˌmakrəʊiːvəˈluːʃ(ə)n, -ɛv-/Definition of macroevolution noun [mass noun] Biology major evolutionary change, especially with regard to the evolution of whole taxonomic groups over long periods of time. Derivatives macroevolutionary adjective macroevolution in other Oxford dictionaries Definition of macroevolution in the US English dictionary