macrocyclicPronunciation: /ˌmakrə(ʊ)ˈsʌɪklɪk, -ˈsɪk-/Definition of macrocyclic adjective Chemistry relating to or denoting a ring composed of a relatively large number of atoms, such as occur in haem, chlorophyll, and several natural antibiotics. Derivatives macrocycle noun macrocyclic in other Oxford dictionaries Definition of macrocyclic in the US English dictionary