lyophilizePronunciation: /lʌɪˈɒfɪlʌɪz/ (also lyophilise)Definition of lyophilize verb [with object] technical freeze-dry (a substance): the resulting precipitate was dissolved in benzene and lyophilized to give a powderDerivatives lyophilization noun lyophilize in other Oxford dictionaries Definition of lyophilize in the US English dictionary