loperamidePronunciation: /ləʊˈpɛrəmʌɪd/Definition of loperamide noun [mass noun] Medicine a synthetic drug of the opiate class which inhibits peristalsis and is used to treat diarrhoea. Origin: 1970s: probably from (ch)lo(ro-) + (pi)per(idine) + amideloperamide in other Oxford dictionaries Definition of loperamide in the US English dictionary