lobotomizePronunciation: /ləˈbɒtəmʌɪz/ (also lobotomise)Definition of lobotomize verb [with object] Surgery perform a lobotomy on: her brother had developed a schizophrenic illness and had been lobotomized informal make (someone) less able to function mentally or emotionally:couples we knew who had been lobotomized by the birth of their childrenDerivatives lobotomization noun lobotomize in other Oxford dictionaries Definition of lobotomize in the US English dictionary