lignocainePronunciation: /ˈlɪgnə(ʊ)keɪn/Definition of lignocaine noun [mass noun] Medicine a synthetic compound used as a local anaesthetic, e.g. for dental surgery, and in treating abnormal heart rhythms. An aromatic amide; chemical formula: C14H22N2O Origin: 1950s: from ligno- (Latin equivalent of xylo-, used in the earlier name xylocaine and reflecting chemical similarity to xylene) + -caine (from cocaine)lignocaine in other Oxford dictionaries Definition of lignocaine in the US English dictionary