lactulosePronunciation: /ˈlaktjʊləʊz/Definition of lactulose noun [mass noun] Chemistry a synthetic sugar with laxative properties. It is a disaccharide consisting of glucose and fructose units. Origin: 1930s: from lacto- 'of milk', perhaps on the pattern of celluloselactulose in other Oxford dictionaries Definition of lactulose in the US English dictionary