isoprenePronunciation: /ˈʌɪsə(ʊ)priːn/Definition of isoprene noun [mass noun] Chemistry a volatile liquid hydrocarbon obtained from petroleum, whose molecule forms the basic structural unit of natural and synthetic rubbers. Chemical formula: CH2C(CH3)CHCH2 Origin: mid 19th century: apparently from iso- 'equal' + pr(opyl)eneisoprene in other Oxford dictionaries Definition of isoprene in the US English dictionary