isatinPronunciation: /ˈʌɪsətɪn/Definition of isatin noun [mass noun] Chemistry a red crystalline compound used in the manufacture of dyes. An indole derivative; chemical formula: C8H5NO2 Origin: mid 19th century: from Latin isatis 'woad' (from Greek) + -in1isatin in other Oxford dictionaries Definition of isatin in the US English dictionary