iontophoresisPronunciation: /ʌɪˌɒntə(ʊ)fəˈriːsɪs/Definition of iontophoresis noun [mass noun] Medicine a technique of introducing ionic medicinal compounds into the body through the skin by applying a local electric current. Origin: early 20th century: from ion, on the pattern of electrophoresisiontophoresis in other Oxford dictionaries Definition of iontophoresis in the US English dictionary