imidazolePronunciation: /ˌɪmɪˈdeɪzəʊl, ɪˈmɪdəzəʊl/Definition of imidazole noun [mass noun] Chemistry a colourless crystalline compound with mildly basic properties, present as a substituent in the amino acid histidine. a heterocyclic compound; chemical formula: C3H4N2 Origin: late 19th century: from imide + azo- + -oleimidazole in other Oxford dictionaries Definition of imidazole in the US English dictionary