ichthyosisPronunciation: /ˌɪkθɪˈəʊsɪs/Definition of ichthyosis noun [mass noun] Medicine a congenital skin condition which causes the epidermis to become dry and horny like fish scales. Derivatives ichthyoticPronunciation: /-ˈɒtɪk/ adjective ichthyosis in other Oxford dictionaries Definition of ichthyosis in the US English dictionary