hypoxiaPronunciation: /hʌɪˈpɒksɪə/Definition of hypoxia noun [mass noun] Medicine deficiency in the amount of oxygen reaching the tissues. oxygen deficiency in a biotic environment:aquatic hypoxiaDerivatives hypoxic adjective Origin: 1940s: from hypo- (denoting an element in a low valency) + oxygen + -ia1hypoxia in other Oxford dictionaries Definition of hypoxia in the US English dictionary