hypogonadismPronunciation: /ˌhʌɪpə(ʊ)ˈgəʊnadɪz(ə)m/Definition of hypogonadism noun [mass noun] Medicine reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries). Derivatives hypogonadal adjective hypogonadic noun & adjective hypogonadism in other Oxford dictionaries Definition of hypogonadism in the US English dictionary