hypertonicPronunciation: /ˌhʌɪpəˈtɒnɪk/Definition of hypertonic adjective 1 Biology having a higher osmotic pressure than a particular fluid, typically a body fluid or intracellular fluid. 2 Physiology of or in a state of abnormally high muscle tone. Derivatives hypertoniaPronunciation: /-ˈtəʊnɪə/ noun hypertonic (sense 2). hypertonicityPronunciation: /-təˈnɪsɪti/ noun hypertonic in other Oxford dictionaries Definition of hypertonic in the US English dictionary