hypericinPronunciation: /hʌɪˈpɛrɪsɪn/Definition of hypericin noun [mass noun] a substance found in St John’s wort, credited with chemical and pharmacological properties similar to those of antidepressants. A polycyclic quinone; chemical formula: C30H14O8 Origin: early 20th century: from hypericum + -in1hypericin in other Oxford dictionaries Definition of hypericin in the US English dictionary