homophilePronunciation: /ˈhɒməfʌɪl, ˈhəʊməfʌɪl/Definition of homophile adjective of or relating to homosexuals. active in supporting the rights of homosexuals:early homophile organizations noun a homosexual person. a person active in supporting the rights of homosexuals. Origin: 1960s: from homosexual + -philehomophile in other Oxford dictionaries Definition of homophile in the US English dictionary