histaminePronunciation: /ˈhɪstəmiːn/Definition of histamine noun [mass noun] Biochemistry a compound which is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries. A heterocyclic amine; chemical formula: C5H9N3 Derivatives histaminicPronunciation: /-ˈmɪnɪk/ adjective Origin: early 20th century: blend of histidine and aminehistamine in other Oxford dictionaries Definition of histamine in the US English dictionary