haptoglobinPronunciation: /ˌhaptə(ʊ)ˈgləʊbɪn/Definition of haptoglobin noun [mass noun] Biochemistry a protein present in blood serum which binds to and removes free haemoglobin from the bloodstream. Origin: 1940s: from Greek haptein 'fasten' + (haemo)globinhaptoglobin in other Oxford dictionaries Definition of haptoglobin in the US English dictionary