handshakePronunciation: /ˈhan(d)ʃeɪk/Translate handshake | into French | into German | into Italian | into Spanish Definition of handshake noun an act of shaking a person’s hand with one’s own as a greeting. Computing an exchange of standardized signals between devices in a computer network regulating the transfer of data. handshake in other Oxford dictionaries Definition of handshake in the US English dictionary