guayulePronunciation: /gwʌɪˈuːli/Definition of guayule noun a silver-leaved Mexican shrub of the daisy family which yields large amounts of latex. Parthenium argentatum, family Compositae [mass noun] a rubber substitute made from the guayule. Origin: early 20th century: via Latin American Spanish from Nahuatl cuauhuliguayule in other Oxford dictionaries Definition of guayule in the US English dictionary