guaranaPronunciation: /gwəˈrɑːnə/Definition of guarana noun 1 [mass noun] a substance prepared from the seeds of a Brazilian shrub, used as a tonic or stimulant. 2the shrub that yields guarana. Paullinia cupana, family Sapindaceae Origin: mid 19th century: from Tupiguarana in other Oxford dictionaries Definition of guarana in the US English dictionary