guanidinePronunciation: /ˈgwɑːnɪdiːn/Definition of guanidine noun [mass noun] Chemistry a strongly basic crystalline compound, used in organic synthesis. An imide derived from urea; chemical formula: HNC(NH2)2 Origin: mid 19th century: from guano + -ide + -ine4guanidine in other Oxford dictionaries Definition of guanidine in the US English dictionary